Conclusions: The increases of serum total bilirubin levels in the neonate could be a response to excessive free radical generation and lipid peroxide formation.
A significant negative correlation was found between malondialdehyde and haemoglobin (P<0.001) in the same groups. Results: The level of malondialdehyde was increased in stepwise manner in the hyperbilirubinaemia groups (G1=4.82 IU/l),(G2=9.21 IU/l), (G3=12.87IU/l), and (G4=17 IU/l).A significant positive correlation was observed between malondialdehyde and bilirubin concentrations in the studied groups G1, G2, and G3 (P<0.001). Materials and Methods: The study included 110 neonates classified into four groups according the total bilirubin (TB) levels: G1 (n=31 TB 5 and 10 and 15 mg/dl). In this study relationship between the levels of serum bilirubin and malondialdehyde was investigated in neonates with different stages of hyperbilirubinaemia.
Malondialdehyde (MDA) is a metabolite commonly used as indicator of free radical generation by lipid peroxidation. Increase of bilirubin production could be a response to an initial oxidative stress. Abstract:Objectives: Bilirubin, a haemoglobin metabolite acts as an efficient scavenger of reactive oxygen species.
